BioSig: An Imaging and Informatic Framework for Representing the Physiological Responses of Living Cells
Biosilico, March 2003.
Subcellular experimental datasets and detailed cell models
are required before modeling of whole organs. Cell modeling
requires repeated interaction between simulation and experimental
data. This review describes a coupled system of bioinformatics
and instrument control suitable for extracting information
at the subcellular level. The BioSig informatics
framework annotates time-series images with experimental
variables computed representation such as physiological responses,
whereas visual servoing optical microscopy (VSOM) is used for adaptive
perturbation and interaction with living cells.
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